Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum.

Plasmodium falciparum, the causative agent of human malaria, expresses two aminopeptidases, PfM1AAP and PfM17LAP, critical to generating a free amino acid pool used by the intraerythrocytic stage of the parasite for proteins synthesis, growth and development. These exopeptidases are potential target...

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Bibliographic Details
Main Authors: Marcin Poreba, Sheena McGowan, Tina S Skinner-Adams, Katharine R Trenholme, Donald L Gardiner, James C Whisstock, Joyce To, Guy S Salvesen, John P Dalton, Marcin Drag
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3281095?pdf=render