PRC1 Prevents Replication Stress during Chondrogenic Transit Amplification

PRC1 Prevents Replication Stress during Chondrogenic Transit Amplification

Transit amplification (TA), a state of combined, rapid proliferative expansion and differentiation of stem cell-descendants, remains poorly defined at the molecular level. The Polycomb Repressive Complex 1 (PRC1) protein BMI1 has been localized to TA compartments, yet its exact role in TA is unclear...

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Bibliographic Details
Main Authors: Frank Spaapen, Lars M. T. Eijssen, Michiel E. Adriaens, Tim J. Welting, Peggy Prickaerts, Juliette Salvaing, Vivian E. H. Dahlmans, Donald A. M. Surtel, Frans Kruitz, Roel Kuijer, Yoshihiro Takihara, Hendrik Marks, Hendrik G. Stunnenberg, Bradly G. Wouters, Miguel Vidal, Jan Willem Voncken
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Epigenomes
Subjects:
polycomb
topoisomerase
transit amplification
chromatin
DNA replication
transcription
chondrogenesis
differentiation
DNA damage
hypertrophy
senescence
Online Access:https://www.mdpi.com/2075-4655/1/3/22

Internet

https://www.mdpi.com/2075-4655/1/3/22

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