The Discovery of Insulin-Regulated Aminopeptidase (IRAP) Inhibitors: A Literature Review

The Discovery of Insulin-Regulated Aminopeptidase (IRAP) Inhibitors: A Literature Review

Insulin-Regulated Aminopeptidase (IRAP, EC 3.4.11.3) is a multi-tasking member of the M1 family of zinc aminopeptidases. Among its diverse biological functions, IRAP is a regulator of oxytocin levels during late stages of pregnancy, it affects cellular glucose uptake by trafficking of the glucose tr...

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Bibliographic Details
Main Authors: Dimitris Georgiadis, Angeliki Ziotopoulou, Eleni Kaloumenou, Angelos Lelis, Antonia Papasava
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
inhibitor
insulin-regulated aminopeptidase
inhibitor selectivity
aminopeptidase
structure-activity relationships
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.585838/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.585838/full

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