Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials

Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials

Peptidoglycan (PG) is an essential macromolecular sacculus surrounding most bacteria. It is assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of multimodular penicillin-binding proteins (PBPs) within multiprotein complex machineries. Both activities are essential for the s...

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Bibliographic Details
Main Authors: Eric Sauvage, Mohammed Terrak
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:Antibiotics
Subjects:
peptidoglycan
glycosyltransferase
transpeptidase
penicillin-binding proteins
β-lactam
lipid II
antibiotics resistance
Online Access:http://www.mdpi.com/2079-6382/5/1/12

Internet

http://www.mdpi.com/2079-6382/5/1/12

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