Genetic ablation of phospholipase C delta 1 increases survival in SOD1G93A mice

Genetic ablation of phospholipase C delta 1 increases survival in SOD1G93A mice

Amyotrophic Lateral Sclerosis (ALS) is a devastating progressive neurodegenerative disease, resulting in selective motor neuron degeneration and paralysis. Patients die approximately 3–5 years after diagnosis. Disease pathophysiology is multifactorial, including excitotoxicity, but is not yet fully...

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Main Authors: Kim A. Staats, Lawrence Van Helleputte, Ashley R. Jones, André Bento-Abreu, Annelies Van Hoecke, Aleksey Shatunov, Claire L. Simpson, Robin Lemmens, Tom Jaspers, Kiyoko Fukami, Yoshikazu Nakamura, Robert H. Brown, Jr., Philip Van Damme, Adrian Liston, Wim Robberecht, Ammar Al-Chalabi, Ludo Van Den Bosch
Format: Article
Language:English
Published: Elsevier 2013-12-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Phospholipase C delta 1
Neurogenetics
SOD1-G93A mice
Excitotoxicity
Motor neuron disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113002271

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http://www.sciencedirect.com/science/article/pii/S0969996113002271

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