Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns
Higher total homocysteine (tHcy) levels, and C677T and A1298C methylenetetrahydrofolate (MTHFR) polymorphisms, have been reported in preterm or full term newborns with neonatal encephalopathy following perinatal hypoxic-ischemic insult. This study investigated the causal role of tHcy and MTHFR polym...
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Online Access: | http://dx.doi.org/10.1155/2015/543134 |
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doaj-eb5bee59f77f49fe8e9d6cb8b6187a1a2020-11-24T20:48:56ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942015-01-01201510.1155/2015/543134543134Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term NewbornsLucia M. Marseglia0Antonio Nicotera1Vincenzo Salpietro2Elisa Giaimo3Giovanna Cardile4Maria Bonsignore5Angela Alibrandi6Daniela Caccamo7Sara Manti8Gabriella D’Angelo9Carmelo Mamì10Gabriella Di Rosa11Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, Unit of Neonatal Intensive Care, University of Messina, Messina, ItalyDepartment of Pediatric, Gynecological, Microbiological and Biomedical Sciences, Unit of Child Neurology and Psychiatry, University of Messina, Messina, ItalyDepartment of Pediatric, Gynecological, Microbiological and Biomedical Sciences, Unit of Pediatric Genetics and Immunology, University of Messina, Messina, ItalyDepartment of Pediatric, Gynecological, Microbiological and Biomedical Sciences, Unit of Child Neurology and Psychiatry, University of Messina, Messina, ItalyDepartment of Pediatric, Gynecological, Microbiological and Biomedical Sciences, Unit of Child Neurology and Psychiatry, University of Messina, Messina, ItalyDepartment of Pediatric, Gynecological, Microbiological and Biomedical Sciences, Unit of Child Neurology and Psychiatry, University of Messina, Messina, ItalyDepartment of Economical, Business and Environmental Sciences and Quantitative Methods, University of Messina, Messina, ItalyDepartment of Biomedical Sciences and Morpho-Functional Imaging, University of Messina, Messina, ItalyDepartment of Pediatric, Gynecological, Microbiological and Biomedical Sciences, Unit of Neonatal Intensive Care, University of Messina, Messina, ItalyDepartment of Pediatric, Gynecological, Microbiological and Biomedical Sciences, Unit of Neonatal Intensive Care, University of Messina, Messina, ItalyDepartment of Pediatric, Gynecological, Microbiological and Biomedical Sciences, Unit of Neonatology, University of Messina, Messina, ItalyDepartment of Pediatric, Gynecological, Microbiological and Biomedical Sciences, Unit of Child Neurology and Psychiatry, University of Messina, Messina, ItalyHigher total homocysteine (tHcy) levels, and C677T and A1298C methylenetetrahydrofolate (MTHFR) polymorphisms, have been reported in preterm or full term newborns with neonatal encephalopathy following perinatal hypoxic-ischemic insult. This study investigated the causal role of tHcy and MTHFR polymorphisms together with other acquired risk factors on the occurrence of brain white matter abnormalities (WMA) detected by cranial ultrasound scans (cUS) in a population of late preterm and full term infants. A total of 171 newborns (81 M, 47.4%), 45 (26.3%) born <37 wks, and 126 (73.7%) born ≥37 wks were recruited in the study. cUS detected predominant WMA pattern in 36/171 newborns (21.1%) mainly characterized by abnormal periventricular white matter signal and mild-to-moderate periventricular white matter volume loss with ventricular dilatation (6/36, 16.6%). WMA resulted in being depending on tHcy levels (P<0.014), lower GA (P<0.000), lower Apgar score at 1 minutes (P<0.000) and 5 minutes (P<0.000), and 1298AC and 677CT/1298AC genotypes (P<0.000 and P<0.000). In conclusion, both acquired and genetic predisposing antenatal factors were significantly associated with adverse neonatal outcome and WMA. The role of A1298C polymorphism may be taken into account for prenatal assessment and treatment counseling.http://dx.doi.org/10.1155/2015/543134 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lucia M. Marseglia Antonio Nicotera Vincenzo Salpietro Elisa Giaimo Giovanna Cardile Maria Bonsignore Angela Alibrandi Daniela Caccamo Sara Manti Gabriella D’Angelo Carmelo Mamì Gabriella Di Rosa |
spellingShingle |
Lucia M. Marseglia Antonio Nicotera Vincenzo Salpietro Elisa Giaimo Giovanna Cardile Maria Bonsignore Angela Alibrandi Daniela Caccamo Sara Manti Gabriella D’Angelo Carmelo Mamì Gabriella Di Rosa Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns Oxidative Medicine and Cellular Longevity |
author_facet |
Lucia M. Marseglia Antonio Nicotera Vincenzo Salpietro Elisa Giaimo Giovanna Cardile Maria Bonsignore Angela Alibrandi Daniela Caccamo Sara Manti Gabriella D’Angelo Carmelo Mamì Gabriella Di Rosa |
author_sort |
Lucia M. Marseglia |
title |
Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns |
title_short |
Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns |
title_full |
Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns |
title_fullStr |
Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns |
title_full_unstemmed |
Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns |
title_sort |
hyperhomocysteinemia and mthfr polymorphisms as antenatal risk factors of white matter abnormalities in two cohorts of late preterm and full term newborns |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2015-01-01 |
description |
Higher total homocysteine (tHcy) levels, and C677T and A1298C methylenetetrahydrofolate (MTHFR) polymorphisms, have been reported in preterm or full term newborns with neonatal encephalopathy following perinatal hypoxic-ischemic insult. This study investigated the causal role of tHcy and MTHFR polymorphisms together with other acquired risk factors on the occurrence of brain white matter abnormalities (WMA) detected by cranial ultrasound scans (cUS) in a population of late preterm and full term infants. A total of 171 newborns (81 M, 47.4%), 45 (26.3%) born <37 wks, and 126 (73.7%) born ≥37 wks were recruited in the study. cUS detected predominant WMA pattern in 36/171 newborns (21.1%) mainly characterized by abnormal periventricular white matter signal and mild-to-moderate periventricular white matter volume loss with ventricular dilatation (6/36, 16.6%). WMA resulted in being depending on tHcy levels (P<0.014), lower GA (P<0.000), lower Apgar score at 1 minutes (P<0.000) and 5 minutes (P<0.000), and 1298AC and 677CT/1298AC genotypes (P<0.000 and P<0.000). In conclusion, both acquired and genetic predisposing antenatal factors were significantly associated with adverse neonatal outcome and WMA. The role of A1298C polymorphism may be taken into account for prenatal assessment and treatment counseling. |
url |
http://dx.doi.org/10.1155/2015/543134 |
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