A role for naturally occurring alleles of Endoplasmic Reticulum Aminopeptidases in tumor immunity and cancer predisposition

A role for naturally occurring alleles of Endoplasmic Reticulum Aminopeptidases in tumor immunity and cancer predisposition

Endoplasmic Reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) are key components on the pathway that generates antigenic epitopes for presentation to cytotoxic T-lymphocytes (CTLs). Coding single nucleotide polymorphisms (SNPs) in these enzymes have been associated with predisposition to several ma...

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Bibliographic Details
Main Authors: Efstratios eStratikos, Athanasios eStamogiannos, Efthalia eZervoudi, Doriana eFruci
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Oncology
Subjects:
Adaptive Immunity
Antigen Presentation
Enzyme Inhibitors
Polymorphism, Single Nucleotide
Cancer
SNP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00363/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00363/full

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