Synthesis, Characterization and Molecular Docking of Novel Bioactive Thiazolyl-Thiazole Derivatives as Promising Cytotoxic Antitumor Drug

Synthesis, Characterization and Molecular Docking of Novel Bioactive Thiazolyl-Thiazole Derivatives as Promising Cytotoxic Antitumor Drug

Reactions of ethylidenethiocarbohydrazide with hydrazonoyl halides gave 1,3-thiazole or 1,3,4-thiadiazole derivatives according to the type of hydrazonoyl halides. Treatment of ethylidenethiosemicarbazide with hydrazonoyl halides and dimethylacetylene dicarboxylate (DMAD) afforded the corresponding...

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Bibliographic Details
Main Authors: Sobhi M. Gomha, Taher A. Salaheldin, Huwaida M. E. Hassaneen, Hassan M. Abdel-Aziz, Mohammed A. Khedr
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
ethylidenethiocarbohydrazide
ethylidenethiosemicarbazide
hydrazonoyl halides
1,3-thiazole
1,3,4-thiadiazole
cytotoxic activity
molecular docking
Online Access:http://www.mdpi.com/1420-3049/21/1/3

Internet

http://www.mdpi.com/1420-3049/21/1/3

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