JAK inhibitors dampen activation of interferon-activated transcriptomes and the SARS-CoV-2 receptor ACE2 in human renal proximal tubules

JAK inhibitors dampen activation of interferon-activated transcriptomes and the SARS-CoV-2 receptor ACE2 in human renal proximal tubules

Summary: SARS-CoV-2 infections initiate cytokine storms and activate genetic programs leading to progressive hyperinflammation in multiple organs of patients with COVID-19. While it is known that COVID-19 impacts kidney function, leading to increased mortality, cytokine response of renal epithelium...

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Bibliographic Details
Main Authors: Jakub Jankowski, Hye Kyung Lee, Julia Wilflingseder, Lothar Hennighausen
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:iScience
Subjects:
Pathophysiology
Virology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221008968

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