EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer

by Kyung Hyun Yoo, Lothar Hennighausen
Published 2012-01-01

JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells

by Hye Kyung Lee, Olive Jung, Lothar Hennighausen
Published 2021-06-01

JAK inhibitors dampen activation of interferon-activated transcriptomes and the SARS-CoV-2 receptor ACE2 in human renal proximal tubules

by Jakub Jankowski, Hye Kyung Lee, Julia Wilflingseder, Lothar Hennighausen
Published 2021-08-01

Genetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancer.

by Jeffrey H Hager, Danielle B Ulanet, Lothar Hennighausen, Douglas Hanahan
Published 2009-01-01

Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2.

by Dana Lau-Corona, Woo Kyun Bae, Lothar Hennighausen, David J Waxman
Published 2020-05-01

Lineage-Specific and Non-specific Cytokine-Sensing Genes Respond Differentially to the Master Regulator STAT5

by Xianke Zeng, Michaela Willi, Ha Youn Shin, Lothar Hennighausen, Chaochen Wang
Published 2016-12-01

MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation.

by Yonatan Feuermann, Keunsoo Kang, Avi Shamay, Gertraud W Robinson, Lothar Hennighausen
Published 2014-01-01

Redundant and non-redundant cytokine-activated enhancers control Csn1s2b expression in the lactating mouse mammary gland

by Hye Kyung Lee, Michaela Willi, Tyler Kuhns, Chengyu Liu, Lothar Hennighausen
Published 2021-04-01

The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy

by Xianke Zeng, Hye Kyung Lee, Chaochen Wang, Precious Achikeh, Chengyu Liu, Lothar Hennighausen
Published 2020-04-01

Loss of STAT1 from Mouse Mammary Epithelium Results in an Increased Neu-Induced Tumor Burden

by Peter J. Klover, William J. Muller, Gertraud W. Robinson, Ruth M. Pfeiffer, Daisuke Yamaji, Lothar Hennighausen
Published 2010-11-01

Targeting fidelity of adenine and cytosine base editors in mouse embryos

by Hye Kyung Lee, Michaela Willi, Shannon M. Miller, Sojung Kim, Chengyu Liu, David R. Liu, Lothar Hennighausen
Published 2018-11-01

Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury

by Julia Wilflingseder, Michaela Willi, Hye Kyung Lee, Hannes Olauson, Jakub Jankowski, Takaharu Ichimura, Reinhold Erben, M. Todd Valerius, Lothar Hennighausen, Joseph V. Bonventre
Published 2020-07-01

CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome

by Ha Youn Shin, Chaochen Wang, Hye Kyung Lee, Kyung Hyun Yoo, Xianke Zeng, Tyler Kuhns, Chul Min Yang, Teresa Mohr, Chengyu Liu, Lothar Hennighausen
Published 2017-05-01

Cytokine-Regulated GADD45G Induces Differentiation and Lineage Selection in Hematopoietic Stem Cells

by Frederic B. Thalheimer, Susanne Wingert, Pangrazio De Giacomo, Nadine Haetscher, Maike Rehage, Boris Brill, Fabian J. Theis, Lothar Hennighausen, Timm Schroeder, Michael A. Rieger
Published 2014-07-01

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

by Alejandro Villarino, Arian Laurence, Gertraud W Robinson, Michael Bonelli, Barbara Dema, Behdad Afzali, Han-Yu Shih, Hong-Wei Sun, Stephen R Brooks, Lothar Hennighausen, Yuka Kanno, John J O'Shea
Published 2016-03-01

Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice.

by Shu-Ping Fu, Hao Hong, Sheng-Feng Lu, Chen-Jun Hu, Hou-Xi Xu, Qian Li, Mei-Ling Yu, Chen Ou, Jian-Zhong Meng, Tian-Lin Wang, Lothar Hennighausen, Bing-Mei Zhu
Published 2017-01-01

Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity.

by Ji-Yeon Lee, Heike Muenzberg, Oksana Gavrilova, Jacquelyn A Reed, Darlene Berryman, Eneida C Villanueva, Gwendolyn W Louis, Gina M Leinninger, Stefano Bertuzzi, Randy J Seeley, Gertraud W Robinson, Martin G Myers, Lothar Hennighausen
Published 2008-01-01

Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community

by Hye Kyung Lee, Ludwig Knabl, Lisa Pipperger, Andre Volland, Priscilla A. Furth, Keunsoo Kang, Harold E. Smith, Ludwig Knabl, Romuald Bellmann, Christina Bernhard, Norbert Kaiser, Hannes Gänzer, Mathias Ströhle, Andreas Walser, Dorothee von Laer, Lothar Hennighausen
Published 2021-02-01

STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System

by Shinya Hidano, Louise M. Randall, Lucas Dawson, Hans K. Dietrich, Christoph Konradt, Peter J. Klover, Beena John, Tajie H. Harris, Qun Fang, Bradley Turek, Takashi Kobayashi, Lothar Hennighausen, Daniel P. Beiting, Anita A. Koshy, Christopher A. Hunter
Published 2016-11-01