Cancer Cachexia Induces Preferential Skeletal Muscle Myosin Loss When Combined With Denervation

Patients with cancer cachexia (CCX) suffer from muscle wasting, which is often but not always accompanied by selective loss of myosin. Here we examined the effects of CCX on muscle mass and myosin heavy chain (MyHC) expression in denervated (DEN) muscles, especially focusing on the protein synthesis...

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Bibliographic Details
Main Authors: Takashi Yamada, Yuki Ashida, Daisuke Tatebayashi, Masami Abe, Koichi Himori
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00445/full