Mifepristone promotes adiponectin production and improves insulin sensitivity in a mouse model of diet-induced-obesity.

The steroid receptor antagonist mifepristone is used as an anti-cancer agent, eliciting both cytostatic and cytotoxic effects on malignant cells. However, the metabolic effects of long-term treatment with mifepristone have remained unclear. The effects of mifepristone on insulin sensitivity and adip...

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Bibliographic Details
Main Authors: Takeshi Hashimoto, Junsuke Igarashi, Arif U Hasan, Koji Ohmori, Masakazu Kohno, Yukiko Nagai, Tetsuo Yamashita, Hiroaki Kosaka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3819252?pdf=render