Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain

Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain

<p>Abstract</p> <p>Background</p> <p>Sublingual (s.l.) administration of soluble protein antigens, inactivated viruses, or virus-like particles has been shown to induce broad immune responses in mucosal and extra-mucosal tissues. Recombinant replication-defective adenov...

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Bibliographic Details
Main Authors: Shim Byoung-Shik, Stadler Konrad, Nguyen Huan, Yun Cheol-Heui, Kim Dong, Chang Jun, Czerkinsky Cecil, Song Man
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Virology Journal
Subjects:
Recombinant adenovirus
Sublingual administration
Severe acute respiratory syndrome
Mucosa
T cell
IgA
Online Access:http://www.virologyj.com/content/9/1/215

Internet

http://www.virologyj.com/content/9/1/215

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