The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts

The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts

The immune suppressants cyclosporin A (CsA) and tacrolimus (FK506) are used worldwide in transplantation medicine to suppress graft rejection. Both CsA and FK506 inhibit the phosphatase calcineurin (CN) whose activity controls the immune receptor-mediated activation of lymphocytes. Downstream target...

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Bibliographic Details
Main Authors: Johannes Baur, Christoph Otto, Ulrich Steger, Stefan Klein-Hessling, Khalid Muhammad, Tobias Pusch, Krisna Murti, Rhoda Wismer, Christoph-Thomas Germer, Ingo Klein, Nora Müller, Edgar Serfling, Andris Avots
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
NFATc1
transplantation
heterologous
CD8+ T cells
ChIPseq
metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01338/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01338/full

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