Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages

Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages

Oncostatin M (OSM) is a secreted cytokine mainly involved in chronic inflammatory and cardiovascular diseases through binding to OSM receptor β (OSMR-β). Recent studies demonstrated that the presence of OSM contributed to the destabilization of atherosclerotic plaque. To investigate whether OSMR-β d...

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Bibliographic Details
Main Authors: Xin Zhang, Jing Li, Juan-Juan Qin, Wen-Lin Cheng, Xueyong Zhu, Fu-Han Gong, Zhigang She, Zan Huang, Hao Xia, Hongliang Li
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Journal of Lipid Research
Subjects:
atherosclerosis
inflammation
Janus kinase 2/signal transducer and activator of transcription 3
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520338256

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http://www.sciencedirect.com/science/article/pii/S0022227520338256

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