Unfaithful maintenance of methylation imprints due to loss of maternal nuclear Dnmt1 during somatic cell nuclear transfer.

Unfaithful maintenance of methylation imprints due to loss of maternal nuclear Dnmt1 during somatic cell nuclear transfer.

The low success rate of somatic cell nuclear transfer (SCNT) in mammalian cloning is largely due to imprinting problems. However, little is known about the mechanisms of reprogramming imprinted genes during SCNT. Parental origin-specific DNA methylation regulates the monoallelic expression of imprin...

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Bibliographic Details
Main Authors: Yanchang Wei, Yanjun Huan, Yongqian Shi, Zhongfeng Liu, Gerelchimeg Bou, Yibo Luo, Li Zhang, Cairong Yang, Qingran Kong, Jiangtian Tian, Ping Xia, Qing-Yuan Sun, ZhongHua Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3098883?pdf=render

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http://europepmc.org/articles/PMC3098883?pdf=render

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