Competing endogenous RNA crosstalk at system level.

microRNAs (miRNAs) regulate gene expression at post-transcriptional level by repressing target RNA molecules. Competition to bind miRNAs tends in turn to correlate their targets, establishing effective RNA-RNA interactions that can influence expression levels, buffer fluctuations and promote signal...

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Bibliographic Details
Main Authors: Mattia Miotto, Enzo Marinari, Andrea De Martino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-11-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1007474