miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling

miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling

The study investigated the regulation of Smad2 by miR-18a and its role in preeclampsia (PE). Bioinformatics analysis showed that both Smad2 and Smad3 were the predicted targets for miR-18a. Mass spectrum analysis showed that two mature Smad2 isoforms existed in human placenta: full length, Smad2(FL)...

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Bibliographic Details
Main Authors: Peng Xu, Zhilang Li, Yongqing Wang, Xin Yu, Xuan Shao, Yu-xia Li, Chun Peng, Yangyu Zhao, Yan-Ling Wang
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
miR-18a
Smad2
placental trophoblast
cell invasion
preeclampsia
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302900

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http://www.sciencedirect.com/science/article/pii/S2162253120302900

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