Relationship between ELA2 gene mutations, clinical and laboratory parameters in severe congenital and cyclic neutropenia

Relationship between ELA2 gene mutations, clinical and laboratory parameters in severe congenital and cyclic neutropenia

  Background: Mutations of ELA2, the gene encoding neutrophil elastase (NE) are known to be associated with cyclic neutropenia (CN) and severe congenital neutropenia (SCN). However, high variability of these mutations has been reported. This study was designed to describe the analysis o...

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Bibliographic Details
Main Authors: Farhoodi A, Ahangari Gh, Chavoshzadeh Z, Ramyar A, Movahedi M, Ghareghozlou M, Fazlolahi M, Heydarzadeh M, Bemanian M H, Mansori M, Zandieh F
Format: Article
Language:fas
Published: Tehran University of Medical Sciences 2007-09-01
Series:Tehran University Medical Journal
Subjects:
Severe chronic neutropenia
congenital neutropenia
neutrophil elastase
ELA2
kostmann’s syndrome
cyclic neutropenia
Online Access:http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3922.pdf&manuscript_id=3922

Internet

http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3922.pdf&manuscript_id=3922

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