Evaluation of New Fluorescent Lipophosphoramidates for Gene Transfer and Biodistribution Studies after Systemic Administration

Evaluation of New Fluorescent Lipophosphoramidates for Gene Transfer and Biodistribution Studies after Systemic Administration

The objective of lung gene therapy is to reach the respiratory epithelial cells in order to deliver a functional nucleic acid sequence. To improve the synthetic carrier’s efficacy, knowledge of their biodistribution and elimination pathways, as well as cellular barriers faced, depending on the admin...

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Bibliographic Details
Main Authors: Nawal Belmadi, Mathieu Berchel, Caroline Denis, Wilfried Berthe, Yann Sibiril, Tony Le Gall, Jean-Pierre Haelters, Paul-Alain Jaffres, Tristan Montier
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:International Journal of Molecular Sciences
Subjects:
cationic lipids
administration way
in situ biodistribution
in vivo fluorescence
pegylated formulations
Online Access:http://www.mdpi.com/1422-0067/16/11/25941

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http://www.mdpi.com/1422-0067/16/11/25941

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