Silencing TRPM7 in mouse cortical astrocytes impairs cell proliferation and migration via ERK and JNK signaling pathways.

Silencing TRPM7 in mouse cortical astrocytes impairs cell proliferation and migration via ERK and JNK signaling pathways.

Transient receptor potential melastatin 7 (TRPM7), a non-selective cation channel, is highly expressed expressed in the brain and plays a critical role in ischemic neuronal death. Astrocyte, the most abundant cell type in central nervous system (CNS), exerts many essential functions in the physiolog...

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Bibliographic Details
Main Authors: Zhao Zeng, Tiandong Leng, Xuechao Feng, Huawei Sun, Koichi Inoue, Li Zhu, Zhi-Gang Xiong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4370640?pdf=render

Internet

http://europepmc.org/articles/PMC4370640?pdf=render

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