Imbalance between Expression of FOXC2 and Its lncRNA in Lymphedema-Distichiasis Caused by Frameshift Mutations

Imbalance between Expression of FOXC2 and Its lncRNA in Lymphedema-Distichiasis Caused by Frameshift Mutations

Forkhead-box C2 (FOXC2) is a transcription factor involved in lymphatic system development. <i>FOXC2</i> mutations cause Lymphedema-distichiasis syndrome (LD). Recently, a natural antisense was identified, called lncRNA FOXC2-AS1, which increases <i>FOXC2</i> mRNA stability....

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Bibliographic Details
Main Authors: Sara Missaglia, Daniela Tavian, Sandro Michelini, Paolo Enrico Maltese, Andrea Bonanomi, Matteo Bertelli
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Genes
Subjects:
Lymphedema-distichiasis syndrome
FOXC2
lncRNA FOXC2-AS1
gene expression
confocal analysis
nuclear aggregates
Online Access:https://www.mdpi.com/2073-4425/12/5/650

Internet

https://www.mdpi.com/2073-4425/12/5/650

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