Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons

Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons

Objective: Leptin modulates food reward via central leptin receptor (LepRb) expressing neurons. Food reward requires stimulation of midbrain dopamine neurons and is modulated by central leptin action, but the exact central mechanisms remain unclear. Stimulatory and inhibitory leptin actions on dopam...

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Bibliographic Details
Main Authors: Amanda Laque, Sangho Yu, Emily Qualls-Creekmore, Sarah Gettys, Candice Schwartzenburg, Kelly Bui, Christopher Rhodes, Hans-Rudolf Berthoud, Christopher D. Morrison, Brenda K. Richards, Heike Münzberg
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Molecular Metabolism
Subjects:
Sucrose
Intralipid
Incentive runway
Lateral hypothalamus
Locus coeruleus
Two-bottle choice
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815001362

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http://www.sciencedirect.com/science/article/pii/S2212877815001362

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