Emi2 Is Essential for Mouse Spermatogenesis

Emi2 Is Essential for Mouse Spermatogenesis

The meiotic functions of Emi2, an inhibitor of the APC/C complex, have been best characterized in oocytes where it mediates metaphase II arrest as a component of the cytostatic factor. We generated knockout mice to determine the in vivo functions of Emi2—in particular, its functions in the testis, w...

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Bibliographic Details
Main Authors: Lakshmi Gopinathan, Radoslaw Szmyd, Diana Low, M. Kasim Diril, Heng-Yu Chang, Vincenzo Coppola, Kui Liu, Lino Tessarollo, Ernesto Guccione, Ans M.M. van Pelt, Philipp Kaldis
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
knockout mice
Emi2
APC/C
meiosis
Cdk1
phosphorylation
spermatogenesis
diplotene
spermatocytes
ovary
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308471

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http://www.sciencedirect.com/science/article/pii/S2211124717308471

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