New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment

New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment

Abstract Background Novel therapeutic strategies are urgently needed for the treatment of metastatic Urothelial Bladder Cancer. DNA damaging repair (DDR) targeting has been introduced in cinical trials for bladder cancer patients that carry alterations in homologous DNA repair genes, letting to envi...

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Bibliographic Details
Main Authors: Daniela Criscuolo, Francesco Morra, Riccardo Giannella, Roberta Visconti, Aniello Cerrato, Angela Celetti
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
DNA damage response
Synthetic lethality
BRCAness
CCDC6
Biomarkers
Immunotherapy
Online Access:http://link.springer.com/article/10.1186/s13046-019-1089-z

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http://link.springer.com/article/10.1186/s13046-019-1089-z

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