Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity

Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity

Summary: Natural killer (NK) cells are cytotoxic innate lymphoid cells (ILCs) that mediate antiviral and antitumor responses and require the transcriptional regulator Eomesodermin (Eomes) for early development. However, the role of Eomes and its molecular program in mature NK cell biology is unclear...

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Bibliographic Details
Main Authors: Julia A. Wagner, Pamela Wong, Timothy Schappe, Melissa M. Berrien-Elliott, Celia Cubitt, Natalia Jaeger, Madeline Lee, Cassie R. Keppel, Nancy D. Marin, Jennifer A. Foltz, Lynne Marsala, Carly C. Neal, Ryan P. Sullivan, Stephanie E. Schneider, Molly P. Keppel, Nermina Saucier, Megan A. Cooper, Todd A. Fehniger
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
NK cell
Ncr1-specific
Eomes
cytotoxicity
homeostasis
inducible-cre model
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306975

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http://www.sciencedirect.com/science/article/pii/S2211124720306975

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