Design, Synthesis and Investigation of the Potential Anti-Inflammatory Activity of 7-<i>O</i>-Amide Hesperetin Derivatives

Design, Synthesis and Investigation of the Potential Anti-Inflammatory Activity of 7-<i>O</i>-Amide Hesperetin Derivatives

To develop new anti-inflammatory agents, a series of 7-<i>O</i>-amide hesperetin derivatives was designed, synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells. All compounds showed inhibitory effect on LPS-induced NO production. Among them, 7-<i>O</i>...

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Bibliographic Details
Main Authors: Yilong Zhang, Yan Zheng, Wen Shi, Yahui Guo, Tao Xu, Zeng Li, Cheng Huang, Jun Li
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molecules
Subjects:
hesperetin derivatives
synthesis
inflammatory
nf-κb
structure-activity relationships.
Online Access:https://www.mdpi.com/1420-3049/24/20/3663

Internet

https://www.mdpi.com/1420-3049/24/20/3663

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