Effect of AAV-mediated overexpression of ATF5 and downstream targets of an integrated stress response in murine skeletal muscle

Abstract We previously reported that growth promoter-induced skeletal muscle hypertrophy co-ordinately upregulated expression of genes associated with an integrated stress response (ISR), as well as potential ISR regulators. We therefore used Adeno-Associated Virus (AAV)-mediated overexpression of t...

Full description

Bibliographic Details
Main Authors: Madelaine C. Brearley-Sholto, David M. Loczenski-Brown, Sarah Jones, Zoe C. T. R. Daniel, Francis J. P. Ebling, Tim Parr, John M. Brameld
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-99432-4