Targeted Gene Delivery through the Respiratory System: Rationale for Intratracheal Gene Transfer

Targeted Gene Delivery through the Respiratory System: Rationale for Intratracheal Gene Transfer

Advances in DNA- and RNA-based technologies have made gene therapy suitable for many lung diseases, especially those that are hereditary. The main objective of gene therapy is to deliver an adequate amount of gene construct to the intended target cell, achieve stable transduction in target cells, an...

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Bibliographic Details
Main Authors: Michael G. Katz, Anthony S. Fargnoli, Sarah M. Gubara, Kenneth Fish, Thomas Weber, Charles R. Bridges, Roger J. Hajjar, Kiyotake Ishikawa
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
gene therapy
lung cellular structure
biological barriers
viral vectors
endotracheal route of delivery
hereditary
mutation
Online Access:https://www.mdpi.com/2308-3425/6/1/8

Internet

https://www.mdpi.com/2308-3425/6/1/8

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