In vitro comparison of hydroxocobalamin (B12a) and the mitochondrial directed therapy by a succinate prodrug in a cellular model of cyanide poisoning

In vitro comparison of hydroxocobalamin (B12a) and the mitochondrial directed therapy by a succinate prodrug in a cellular model of cyanide poisoning

The objective of this study was to compare the use of hydroxocobalamin (B12a) and a succinate prodrug to evaluate for improvement in mitochondrial function in an in vitro model of cyanide poisoning. Peripheral blood mononuclear cells (PBMC) and human aortic smooth muscle cells (HASMC) incubated with...

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Bibliographic Details
Main Authors: Shawn Owiredu, Abhay Ranganathan, John C. Greenwood, Sarah Piel, Joanna I. Janowska, David M. Eckmann, Matthew Kelly, Johannes K. Ehinger, Todd J. Kilbaugh, David H. Jang
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Toxicology Reports
Subjects:
Respiration
Cyanide
Mitochondria
Antidote
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750020303966

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http://www.sciencedirect.com/science/article/pii/S2214750020303966

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