Effect of PEGylation on assembly morphology and cellular uptake of poly ethyleneimine-cholesterol conjugates for delivery of sorafenib tosylate in hepatocellular carcinoma

Effect of PEGylation on assembly morphology and cellular uptake of poly ethyleneimine-cholesterol conjugates for delivery of sorafenib tosylate in hepatocellular carcinoma

Introduction: Sorafenib (SFB) is an FDA-approved chemotherapeutic agent with a high partition coefficient (log P = 4.34) for monotherapy of hepatocellular carcinoma (HCC). The oral bioavailability is low and variable, so it was aimed to study the application of the polymeric nanoassembly of choleste...

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Bibliographic Details
Main Authors: Maryam Monajati, Shirin Tavakoli, Samira Sadat Abolmaali, Gholamhossein Yousefi, AliMohammad Tamaddon
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2018-07-01
Series:BioImpacts
Subjects:
poly ethyleneimine
cholesterol
lipopolymer
pegylation
polymeric micelles
sorafenib tosylate
hepatocellular carcinoma
Online Access:https://bi.tbzmed.ac.ir/PDF/bi-8-241.pdf

Internet

https://bi.tbzmed.ac.ir/PDF/bi-8-241.pdf

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