A critical role for hemolysin in Vibrio fluvialis-induced IL-1β secretion mediated by the NLRP3 inflammasome in macrophages

A critical role for hemolysin in Vibrio fluvialis-induced IL-1β secretion mediated by the NLRP3 inflammasome in macrophages

V. fluvialis causes human diarrhea, but the pathogenesis is not well studied. We hypothesized that V. fluvialis-secreted hemolysin (VFH) may induce IL-1β secretion through the activation of the NLRP3 inflammasome and contribute to the pathogenicity of V. fluvialis. To examine this possibility, we co...

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Bibliographic Details
Main Authors: Liqiong eSong, Yuanming eHuang, Meng eZhao, Zhihao eWang, Hui eSun, Shujing eWang, Biao eKan, Guangxun eMeng, Weili eLiang, Zhihong eRen
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Microbiology
Subjects:
Macrophages
IL-1β
hemolysin
Vibrio fluvialis
NLRP3 inflammasomes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00510/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00510/full

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