Arsenic Trioxide Enhances the NK Cell Cytotoxicity Against Acute Promyelocytic Leukemia While Simultaneously Inhibiting Its Bio-Genesis

Arsenic Trioxide Enhances the NK Cell Cytotoxicity Against Acute Promyelocytic Leukemia While Simultaneously Inhibiting Its Bio-Genesis

Natural killer cells (NK) contribute significantly to eradication of cancer cells, and there is increased interest in strategies to enhance it’s efficacy. Therapeutic agents used in the treatment of cancer can impact the immune system in a quantitative and qualitative manner. In this study, we evalu...

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Bibliographic Details
Main Authors: Ansu Abu Alex, Saravanan Ganesan, Hamenth Kumar Palani, Nithya Balasundaram, Sachin David, Kavitha M. Lakshmi, Uday P. Kulkarni, P. N. Nisham, Anu Korula, Anup J. Devasia, Nancy Beryl Janet, Aby Abraham, Alok Srivastava, Biju George, Rose Ann Padua, Christine Chomienne, Poonkuzhali Balasubramanian, Vikram Mathews
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
natural killer cells
arsenic trioxide
immune response
acute promyelocytic leukemia
APL mouse model
NK cellular therapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01357/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01357/full

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