Combination of DNA prime--adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model.

Combination of DNA prime--adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model.

A potent therapeutic T-cell vaccine may be an alternative treatment of chronic hepatitis B virus (HBV) infection. Previously, we developed a DNA prime-adenovirus (AdV) boost vaccination protocol that could elicit strong and specific CD8+ T-cell responses to woodchuck hepatitis virus (WHV) core antig...

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Bibliographic Details
Main Authors: Anna D Kosinska, Ejuan Zhang, Lena Johrden, Jia Liu, Pia L Seiz, Xiaoyong Zhang, Zhiyong Ma, Thekla Kemper, Melanie Fiedler, Dieter Glebe, Oliver Wildner, Ulf Dittmer, Mengji Lu, Michael Roggendorf
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3681757?pdf=render

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http://europepmc.org/articles/PMC3681757?pdf=render

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