Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca2+ channels

Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca2+ channels

Inhibitions and antagonists of L-type Ca2+ channels are important to both research and therapeutics. Here, we report C-terminus mediated inhibition (CMI) for CaV1.3 that multiple motifs coordinate to tune down Ca2+ current and Ca2+ influx toward the lower limits determined by end-stage CDI (Ca2+-dep...

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Bibliographic Details
Main Authors: Nan Liu, Yaxiong Yang, Lin Ge, Min Liu, Henry M Colecraft, Xiaodong Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
L-type Ca2+ channels
Ca2+ channel inhibition
calmodulin
distal carboxyl terminus
Ca2+ dependent inactivation
Online Access:https://elifesciences.org/articles/21989

Internet

https://elifesciences.org/articles/21989

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