Treatment with a novel oleic-acid–dihydroxyamphetamine conjugation ameliorates non-alcoholic fatty liver disease in obese Zucker rats

Treatment with a novel oleic-acid–dihydroxyamphetamine conjugation ameliorates non-alcoholic fatty liver disease in obese Zucker rats

Fatty liver disease is one of the main hepatic complications associated with obesity. To date, there are no effective treatments for this pathology apart from the use of classical fibrates. In this study, we have characterized the in vivo effects of a novel conjugation of oleic acid with an amphetam...

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Bibliographic Details
Main Authors: Juan M. Decara, Francisco Javier Pavón, Juan Suárez, Miguel Romero-Cuevas, Elena Baixeras, Mariam Vázquez, Patricia Rivera, Ana L. Gavito, Bruno Almeida, Jesús Joglar, Rafael de la Torre, Fernando Rodríguez de Fonseca, Antonia Serrano
Format: Article
Language:English
Published: The Company of Biologists 2015-10-01
Series:Disease Models & Mechanisms
Subjects:
Obesity
Non-alcoholic fatty liver disease
Zucker rats
Cannabinoid type 1 receptor
CB1
Peroxisome proliferator activated-receptor α
PPAR-α
Online Access:http://dmm.biologists.org/content/8/10/1213

Internet

http://dmm.biologists.org/content/8/10/1213

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