The Binding Affinity and Molecular Basis of the Structure-Binding Relationship between Urinary Tamm-Horsfall Glycoprotein and Tumor Necrosis Factor-α

The Binding Affinity and Molecular Basis of the Structure-Binding Relationship between Urinary Tamm-Horsfall Glycoprotein and Tumor Necrosis Factor-α

In a previous study we noted significant THP binding to TNF-α, but did not explore the molecular basis of the structure-binding relationship. In this study, we used lectin-binding ELISA to assess the carbohydrate compositions of THP, BSA, IgG, TNF-α, and IFN-g. We identified β(1,4)-N-acetylglucosami...

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Bibliographic Details
Main Authors: Chia-Li Yu, Chang-Youh Tsai, Tsai-Hung Wu, Sue-Cien Siao, Yu-Hsuan Chen, Ko-Jen Li, Cheng-Han Wu
Format: Article
Language:English
Published: MDPI AG 2012-10-01
Series:Molecules
Subjects:
Tamm-Horsfall glycoprotein
tumor necrosis factor-α
binding affinity
structure-binding relationship
glucosamine-containing mannose
Online Access:http://www.mdpi.com/1420-3049/17/10/11978

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http://www.mdpi.com/1420-3049/17/10/11978

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