Aβ-specific T-cells reverse cognitive decline and synaptic loss in Alzheimer's mice

Aβ-specific T-cells reverse cognitive decline and synaptic loss in Alzheimer's mice

Active and passive Aβ immunotherapy provide behavioral benefits in AD transgenic mice, but they can also induce adverse immune over-activation and neuropathological effects. Here, we show that a restricted Aβ-specific immune re-activation can provide cognitive and pathological benefits to APPsw + PS...

Full description

Bibliographic Details
Main Authors: Douglas W. Ethell, Daniel Shippy, Chuanhai Cao, Jennifer R. Cracchiolo, Melissa Runfeldt, Brett Blake, Gary W. Arendash
Format: Article
Language:English
Published: Elsevier 2006-08-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Adoptive transfer
Beta-amyloid
Cognitive impairment
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000738

Internet

http://www.sciencedirect.com/science/article/pii/S0969996106000738

Similar Items