CSF Proteomic Alzheimer’s Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals

CSF Proteomic Alzheimer’s Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals

We recently discovered three distinct pathophysiological subtypes in Alzheimer’s disease (AD) using cerebrospinal fluid (CSF) proteomics: one with neuronal hyperplasticity, a second with innate immune system activation, and a third subtype with blood–brain barrier dysfunction. It remains unclear whe...

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Bibliographic Details
Main Authors: Betty Marije Tijms, Johan Gobom, Charlotte Teunissen, Valerija Dobricic, Magda Tsolaki, Frans Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuévo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Lars Bertram, Simon Lovestone, Johannes Streffer, Stephanie Vos, ADNI, Kaj Blennow, Philip Scheltens, Henrik Zetterberg, Pieter Jelle Visser
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Proteomes
Subjects:
Alzheimer’s disease
cerebrospinal fluid proteomics
risk factors
cognitive functioning
amyloid beta
tau
Online Access:https://www.mdpi.com/2227-7382/9/3/36

Internet

https://www.mdpi.com/2227-7382/9/3/36

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