Mitochondrial Metabolism as Target of the Neuroprotective Role of Erythropoietin in Parkinson’s Disease

Mitochondrial Metabolism as Target of the Neuroprotective Role of Erythropoietin in Parkinson’s Disease

Existing therapies for Parkinson’s disease (PD) are only symptomatic. As erythropoietin (EPO) is emerging for its benefits in neurodegenerative diseases, here, we test the protective effect driven by EPO in in vitro (SH-SY5Y cells challenged by MPP<sup>+</sup>) and in vivo (C57BL/6J mice...

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Bibliographic Details
Main Authors: Federica Rey, Sara Ottolenghi, Toniella Giallongo, Alice Balsari, Carla Martinelli, Robert Rey, Raffaele Allevi, Anna Maria Di Giulio, Gian Vincenzo Zuccotti, Serena Mazzucchelli, Roberta Foresti, Michele Samaja, Stephana Carelli
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Antioxidants
Subjects:
erythropoietin (EPO)
redox imbalance
Parkinson’s disease
mitochondrial metabolism
neuroprotection
tyrosine hydroxylase (TH)
Online Access:https://www.mdpi.com/2076-3921/10/1/121

Internet

https://www.mdpi.com/2076-3921/10/1/121

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