Computational approach to understanding the mechanism of action of isoniazid, an anti-TB drug

Computational approach to understanding the mechanism of action of isoniazid, an anti-TB drug

Tuberculosis (TB) is an ancient disease caused by Mycobacterium tuberculosis (MTB), which remains a major cause for morbidity and mortality in several developing countries. Most drug-resistant MTB clinical strains are resistant to isoniazid (INH), a first-line anti-TB drug. Mutation in KatG, a catal...

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Bibliographic Details
Main Authors: Lingaraja Jena, Pranita Waghmare, Supriya Kashikar, Satish Kumar, Bhaskar C Harinath
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:International Journal of Mycobacteriology
Subjects:
Isoniazid
KatG
InhA
Drug resistance
Mutation
Online Access:http://www.ijmyco.org/article.asp?issn=2212-5531;year=2014;volume=3;issue=4;spage=276;epage=282;aulast=Jena

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http://www.ijmyco.org/article.asp?issn=2212-5531;year=2014;volume=3;issue=4;spage=276;epage=282;aulast=Jena

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