Genetic Analysis of Synphilin-1 in Familial Parkinson's Disease

Genetic Analysis of Synphilin-1 in Familial Parkinson's Disease

α-Synuclein is present in Lewy bodies of patients with both sporadic and familial Parkinson's disease. However, pathogenic mutations Ala30Pro and Ala53Thr in α-synuclein are rare causes of disease. Synphilin-1 has been demonstrated to associate with α-synuclein and promote the formation of cyto...

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Main Authors: M. Farrer, A. Destée, C. Levecque, A. Singleton, S. Engelender, E. Becquet, V. Mouroux, F. Richard, L. Defebvre, R. Crook, D. Hernandez, C.A. Ross, J. Hardy, P. Amouyel, M-C. Chartier-Harlin
Format: Article
Language:English
Published: Elsevier 2001-04-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996100903267

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http://www.sciencedirect.com/science/article/pii/S0969996100903267

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