Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes

Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes

Mutational activation of the BRAF proto-oncogene in melanocytes reliably produces benign nevi (pigmented ‘moles’), yet the same change is the most common driver mutation in melanoma. The reason nevi stop growing, and do not progress to melanoma, is widely attributed to a cell-autonomous process of ‘...

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Bibliographic Details
Main Authors: Rolando Ruiz-Vega, Chi-Fen Chen, Emaad Razzak, Priya Vasudeva, Tatiana B Krasieva, Jessica Shiu, Michael G Caldwell, Huaming Yan, John Lowengrub, Anand K Ganesan, Arthur D Lander
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
nevus
melanocytes
braf mutation
oncogene induced senescence
nevus mouse model
skin
Online Access:https://elifesciences.org/articles/61026

Internet

https://elifesciences.org/articles/61026

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