T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1b with TAP-Independent Peptides Are Semi-Invariant Lymphocytes

T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1b with TAP-Independent Peptides Are Semi-Invariant Lymphocytes

The HLA-E homolog in the mouse (Qa-1b) is a conserved MHC class Ib molecule presenting monomorphic peptides to germline-encoded natural killer receptor CD94/NKG2A. Previously, we demonstrated the replacement of this canonical peptide by a diverse peptidome upon deficiency of the TAP peptide transpor...

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Bibliographic Details
Main Authors: Elien M. Doorduijn, Marjolein Sluijter, Bianca J. Querido, Ursula J. E. Seidel, Claudia C. Oliveira, Sjoerd H. van der Burg, Thorbald van Hall
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
CD8+ T cells
Qa-1b
non-classical MHC
peptide transporter TAP
T cell receptor
thymus
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00060/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00060/full

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