Accelerated Dystrophy and Decay of Oligodendrocyte Precursor Cells in the APP/PS1 Model of Alzheimer’s-Like Pathology

Accelerated Dystrophy and Decay of Oligodendrocyte Precursor Cells in the APP/PS1 Model of Alzheimer’s-Like Pathology

Myelin disruption is a feature of natural aging and Alzheimer’s disease (AD). In the CNS, myelin is produced by oligodendrocytes, which are generated throughout life by oligodendrocyte progenitor cells (OPCs). Here, we examined age-related changes in OPCs in APP/PS1 mice, a model for AD-like patholo...

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Bibliographic Details
Main Authors: Irene Chacon-De-La-Rocha, Gemma Fryatt, Andrea D. Rivera, Alexei Verkhratsky, Olivier Raineteau, Diego Gomez-Nicola, Arthur M. Butt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
hippocampus
myelin
OPC
oligodendrocyte progenitor cell
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.575082/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2020.575082/full

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