Diabetes insipidus in mice with a mutation in aquaporin-2.

Congenital nephrogenic diabetes insipidus (NDI) is a disease characterized by failure of the kidney to concentrate urine in response to vasopressin. Human kindreds with nephrogenic diabetes insipidus have been found to harbor mutations in the vasopressin receptor 2 (Avpr2) gene or the vasopressin-se...

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Bibliographic Details
Main Authors: David J Lloyd, Frank Wesley Hall, Lisa M Tarantino, Nicholas Gekakis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2005-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1189073?pdf=render