Six2 Plays an Intrinsic Role in Regulating Proliferation of Mesenchymal Cells in the Developing Palate

Six2 Plays an Intrinsic Role in Regulating Proliferation of Mesenchymal Cells in the Developing Palate

Cleft palate is a common congenital abnormality that results from defective secondary palate (SP) formation. The Sine oculis-related homeobox 2 (Six2) gene has been linked to abnormalities of craniofacial and kidney development. Our current study examined, for the first time, the specific role of Si...

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Bibliographic Details
Main Authors: Dennis O. Okello, Paul P. R. Iyyanar, William M. Kulyk, Tara M. Smith, Scott Lozanoff, Shaoping Ji, Adil J. Nazarali
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Physiology
Subjects:
Six2
palate
Hoxa2
craniofacial development
cell proliferation
Cyclin D1
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00955/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00955/full

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