Cues to Opening Mechanisms From in Silico Electric Field Excitation of Cx26 Hemichannel and in Vitro Mutagenesis Studies in HeLa Transfectans

Cues to Opening Mechanisms From in Silico Electric Field Excitation of Cx26 Hemichannel and in Vitro Mutagenesis Studies in HeLa Transfectans

Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and extracellular milieu. Our understanding of the structure-function relationship of connexin channels relies on X-ray crystallographic data for human c...

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Bibliographic Details
Main Authors: Francesco Zonta, Damiano Buratto, Giulia Crispino, Andrea Carrer, Francesca Bruno, Guang Yang, Fabio Mammano, Sergio Pantano
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
gap junction hemichannels
coarse grained simulations
connexin
electrophysiology
Cx26
SIRAH force field
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00170/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00170/full

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