RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses

RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses

All synapses require fusion-competent vesicles and coordinated Ca2+-secretion coupling for neurotransmission, yet functional and anatomical properties are diverse across different synapse types. We show that the presynaptic protein RIM-BP2 has diversified functions in neurotransmitter release at dif...

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Bibliographic Details
Main Authors: Marisa M Brockmann, Marta Maglione, Claudia G Willmes, Alexander Stumpf, Boris A Bouazza, Laura M Velasquez, M Katharina Grauel, Prateep Beed, Martin Lehmann, Niclas Gimber, Jan Schmoranzer, Stephan J Sigrist, Christian Rosenmund, Dietmar Schmitz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
neurotransmitter release
active zone
vesicle priming
calcium channel
hippocampus
Online Access:https://elifesciences.org/articles/43243

Internet

https://elifesciences.org/articles/43243

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