Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration

Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration

To assess targeting of an epothilone folate conjugate (BMS-753493) to the folate receptor (FR)-overexpressed tumor in mice bearing both FR+ and FR– tumors, a series of experiments were conducted by quantitative whole-body autoradiography (QWBA) and LC–MS/MS following i.v. administration of BMS-75349...

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Bibliographic Details
Main Authors: Hong Shen, Lifei Wang, Weiqi Chen, Krista Menard, Yang Hong, Yuan Tian, Samuel J. Bonacorsi, W. Griffith Humphreys, Francis Y. Lee, Jinping Gan
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Folate receptor
Tumor selective targeting
Folate receptor–expressing tumor
Epothilone folate conjugate
Tissue distribution
Tumor uptake
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383516301058

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http://www.sciencedirect.com/science/article/pii/S2211383516301058

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